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  • Title: Asymmetric Total Synthesis of the Indole Diterpene Alkaloid Paspaline.
    Author: Sharpe RJ, Johnson JS.
    Journal: J Org Chem; 2015 Oct 02; 80(19):9740-66. PubMed ID: 26398568.
    Abstract:
    An enantioselective synthesis of the indole diterpenoid natural product paspaline is disclosed. Critical to this approach was the implementation of stereoselective desymmetrization reactions to assemble key stereocenters of the molecule. The design and execution of these tactics are described in detail, and a thorough analysis of observed outcomes is presented, ultimately providing the title compound in high stereopurity. This synthesis provides a novel template for preparing key stereocenters in this family of molecules, and the reactions developed en route to paspaline present a series of new synthetic disconnections in preparing steroidal natural products.
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