These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The Effects of Curcumin-based Compounds on Proliferation and Cell Death in Cervical Cancer Cells.
    Author: Zhang X, Wang R, Chen G, Dejean L, Chen QH.
    Journal: Anticancer Res; 2015 Oct; 35(10):5293-8. PubMed ID: 26408689.
    Abstract:
    AIM: To systematically investigate the effects of a class of curcumin-based compounds on cancer cell viability, proliferation, and apoptosis. MATERIALS AND METHODS: Cytotoxicity and anti-proliferative potency were estimated by the trypan blue exclusion assay and WST-1 cell proliferation assay, respectively. Cell death pathways were discriminated according to plasma membrane integrity and lipid asymmetry cell profiles using a F2N12S and CYTOX AADvanced double staining flow cytometry-based assay. RESULTS: Nine compounds ( 2-10: ) exhibit 13- to 58-fold better cytotoxic and anti-proliferative potencies than curcumin towards HeLa cells. In this cervical cancer cell model, dienone and 1-methylpiperidone serve as the favorable central linkers; 5-methylisoxazol-3-yl and 3-methylisoxazol-5-yl act as the optimal terminal aromatic moiety. Finally, the effects of compounds 6: and 10: on HeLa cells' plasma membrane integrity and lipid asymmetry suggest that the early cytotoxic effect of these compounds is due to a stimulation of apoptosis.
    [Abstract] [Full Text] [Related] [New Search]