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  • Title: Anakinra induces complete remission of nephrotic syndrome in a patient with familial mediterranean fever and amyloidosis.
    Author: Sevillano ÁM, Hernandez E, Gonzalez E, Mateo I, Gutierrez E, Morales E, Praga M.
    Journal: Nefrologia; 2016; 36(1):63-6. PubMed ID: 26409501.
    Abstract:
    Renal amyloidosis is one of the most severe complications of familial Mediterranean fever (FMF). Colchicine has reduced the incidence of this complication, which now only appears in untreated, under-treated and resistant patients, but it is usually ineffective in patients with advanced amyloidosis. Here we report a patient with FMF and biopsy-proven amyloidosis who presented with nephrotic syndrome despite colchicine treatment. Anakinra (an interleukin-1β inhibitor) was started and a dramatic complete remission of nephrotic syndrome was observed in the following months. Anakinra can be an effective treatment for FMF patients with severe secondary amyloidosis.
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