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  • Title: [Effects of tobacco smoke applied on various levels of the respiratory tract].
    Author: Dawid-Milner MS, Lara JP, Díaz-Calavia EJ, Narváez JA, Clavijo E, González-Barón S.
    Journal: Rev Esp Fisiol; 1989; 45 Suppl():197-202. PubMed ID: 2641821.
    Abstract:
    The respiratory and cardiovascular reflex responses of tobacco smoke inhaled through an isolated larynx and directly into the lungs were studied in cats. The inhalation of tobacco smoke directly into the lungs showed the following: tachypnea (p less than 0.01), an increase in inspiratory and expiratory pleural pressure (p less than 0.01, p less than 0.001) with an increase in total lung resistance (p less than 0.01), a decrease in inspiratory and expiratory subglottic pressure (p less than 0.001, p less than 0.02) and an increase in mean arterial pressure (p less than 0.001) with a non significant slight increase of cardiac rate. The inhalation through an isolated larynx showed: bradypnea (p less than 0.01), a non significative decrease in inspiratory and expiratory pleural pressure with no changes in total lung resistance, and an increase in expiratory subglottic pressure (p less than 0.01) with no changes in inspiratory pressure accompanied by several glottic closures. No changes in arterial pressure and cardiac rate were observed. This study shows the existence of two respiratory reflex responses induced by tobacco smoke depending on the respiratory airway level application.
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