These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Positive inotropic effect of cycloprotobuxine-A on isolated guinea pig myocardium.
    Author: Wang YX, Liu JW, Tan YH, Sheng BH.
    Journal: Zhongguo Yao Li Xue Bao; 1989 Nov; 10(6):516-9. PubMed ID: 2641848.
    Abstract:
    Cycloprotobuxine-A (CPB-A) 0.1-100 mumoles/L produced positive inotropic effects in left and right atria in a concentration-dependent manner. CPB-A 30 mumoles/L enhanced post-rest contraction, augmented the response of left atrium to increase in stimulating frequency, and increased the developing tension evoked by paired pulse stimulation. By taking simultaneous recordings of action potentials and contractile force of papillary muscles, it was found that CPB-A 30 mumoles/L increased the contractile force and prolonged the action potential duration at 50% of depolarization. It is concluded that the positive inotropic effect of CPB-A on myocardium may be associated with an increase in transsarcolemmal influx of calcium as well as an augmentation of the amount of calcium released from intracellular stores.
    [Abstract] [Full Text] [Related] [New Search]