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  • Title: Effects of supplementation with a combination of β-hydroxy-β-methyl butyrate, L-arginine, and L-glutamine on postoperative recovery of quadriceps muscle strength after total knee arthroplasty.
    Author: Nishizaki K, Ikegami H, Tanaka Y, Imai R, Matsumura H.
    Journal: Asia Pac J Clin Nutr; 2015; 24(3):412-20. PubMed ID: 26420181.
    Abstract:
    OBJECTIVES: Total knee arthroplasty (TKA) performed in knee osteoarthritis patients is reported to be immediately followed by a decrease in quadriceps muscle strength. We investigated the effects of supplementation with a combination β-hydroxy-β-methyl butyrate, L-arginine, and L-glutamine (HMB/Arg/Gln) on the postoperative recovery of quadriceps muscle strength in patients after TKA. METHODS: Study subjects were 23 patients (12 women; mean age: 70.5) who underwent TKA. The patients were randomly allocated into the control group or the group that consumed HMB/Arg/Gln supplementation (HMB/Arg/Gln group). HMB/Arg/Gln supplementation or control food were consumed for 5 days before the surgery and for 28 days after the surgery, and maximal quadriceps strength was measured at 7 days before the surgery, and at 14, 28 and 42 days after the surgery. During the study, total energy expenditure was measured using a lifestyle recording device. The two groups followed the rehabilitation in the same way. RESULTS: The maximal quadriceps strength was 1.1±0.62 Nm/Kg before surgery and 0.7±0.9 Nm/Kg after surgery 14 days in the control group (p=0.02), and 1.1±0.3 Nm/Kg before surgery and 0.9±0.4 Nm/Kg after surgery 14 days in the HMB/Arg/Gln group. Although the control group experienced a significant loss of muscle strength after the surgery, the HMB/Arg/Gln group did not. There was no significant difference in total energy expenditure between the two groups. CONCLUSIONS: Consuming HMB/Arg/Gln supplementation may suppress the loss of muscle strength after TKA. Intervention with exercise and nutrition appears to enable patients to maintain their quadriceps strength. 目的：有报道称膝关节炎病人全膝关节置换术后，紧接着就是股四头肌肌肉 力量的减小。我们研究了联合补充β羟基β- 甲基丁酸、L-精氨酸和L-谷氨酰 胺（HMB/Arg/Gln）对全膝关节置换患者术后股四头肌肌肉力量恢复的效果。 方法：研究对象为进行全膝关节置换的23 位患者（平均年龄为70.5 岁，其中 12 名为女性）。患者被随机分配进对照组和HMB/Arg/Gln 补充组。手术前补 充5 天和手术后补充28 天的HMB/Arg/Gln 或对照食物。分别在术前7 天，术 后14 天、28 天和42 天测定最大股四头肌力量。在研究过程中，使用一个生 活方式记录装置测定总的能量消耗。随后两组以同样的方式康复。结果：对 照组手术前最大股四头肌力量为1.1±0.62 Nm/Kg，手术后14 天为0.7±0.9 Nm/Kg（p=0.02 ）； HMB/Arg/Gln 组手术前最大股四头肌力量为1.1±0.3 Nm/Kg，手术后14 天为0.9±0.4 Nm/Kg。对照组手术后肌肉力量损失显著，但 HMB/Arg/Gln 组没有。两组之间能量消耗没有显著差异。结论： 补充 HMB/Arg/Gln 可以抑制全膝关节置换术后肌肉力量的损失。运动和营养干预 似乎能够让患者保持他们的股四头肌力量。.
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