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  • Title: Neurostimulation for cognitive rehabilitation in stroke (NeuroCog): study protocol for a randomized controlled trial.
    Author: Andrade SM, Fernández-Calvo B, Boggio PS, de Oliveira EA, Gomes LF, Pinheiro Júnior JE, Rodrigues RM, de Almeida NL, Moreira GM, Alves NT.
    Journal: Trials; 2015 Sep 29; 16():435. PubMed ID: 26420269.
    Abstract:
    BACKGROUND: Stroke patients may present severe cognitive impairments, primarily related to executive functions. Transcranial direct current stimulation has shown promising results, with neuromodulatory and neuroplastic effects. This study is a double-blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different cognitive regions after a stroke. METHODS/DESIGN: Sixty patients who suffer from chronic strokes will be randomized into one of four groups: dorsolateral prefrontal cortex, cingulo-opercular network, motor primary cortex and sham stimulation. Each group will receive transcranial direct current stimulation at an intensity of 2 mA for 20 minutes daily for 10 consecutive days. Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency Test, categorical verbal fluency and Go-no go tests, Wechsler Adult Intelligence Scale, Rey Auditory-Verbal Learning Test, Letter Comparison and Pattern Comparison Tasks at baseline and after their tenth stimulation session. Those who achieve clinical improvement with neurostimulation will be invited to receive treatment for 12 months as part of a follow-up study. DISCUSSION: Long-term stimulation could be analyzed in regard to possible adaptive changes on plasticity after structural brain damage and if these changes are different in terms of clinical improvement when applied to two important cognitive centers. TRIALS REGISTRATION: Clinicaltrials.gov, NCT02315807 . 9 December 2014.
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