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  • Title: Pharmacokinetic data of propranolol enantiomers in a comparative human study with (S)- and (R,S)-propranolol.
    Author: Lindner W, Rath M, Stoschitzky K, Semmelrock HJ.
    Journal: Chirality; 1989; 1(1):10-3. PubMed ID: 2642031.
    Abstract:
    The pharmacokinetics of (S)-propranolol were compared after the oral administration of a 40 mg dose of the pure enantiomer and an 80 mg dose of a racemic mixture of (R,S)-propranolol. The results of this study indicate that the bioavailability of (S)-propranolol, as expressed by the mean area under the concentration-time curve (AUC) and maximum serum concentration, is lower after 40 mg of the optically pure drug than after the racemic drug.
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