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  • Title: Identification of immunoreactive gastrin-releasing peptide related substances in adult rat Leydig cells.
    Author: Gnessi L, Isidori A, Bolotti M, Altamura S, Ulisse S, Jannini EA, Fabbri A, Spera G.
    Journal: Endocrinology; 1989 Jan; 124(1):558-60. PubMed ID: 2642423.
    Abstract:
    Purified adult rat Leydig cells were found to produce gastrin-releasing peptide (GRP) by radioimmunoassay (RIA). Gel chromatography of the extracted material showed a single peak of GRP immunoreactivity. Further high pressure liquid chromatography (HPLC) analysis resolved the extract into two peaks that closely resembled the C-terminal fragment of GRP, GRP18-27 and GRP14-27. Immunohistochemical studies revealed specific staining for GRP in the Leydig cells of adult rat testis. These results demonstrate, by a number of independent criteria, that rat Leydig cells contain substances which behave like authentic GRP-like peptides. Since the peptides appear to be of local origin, a paracrine function within the rat testis is suggested.
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