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  • Title: 46-53 kilodalton glycoprotein from the surface of Plasmodium falciparum merozoites.
    Author: Clark JT, Donachie S, Anand R, Wilson CF, Heidrich HG, McBride JS.
    Journal: Mol Biochem Parasitol; 1989 Jan 01; 32(1):15-24. PubMed ID: 2643035.
    Abstract:
    A 46-53 kDa glycoprotein antigen of Plasmodium falciparum merozoites has been identified using a murine monoclonal antibody that inhibits infection of human erythrocytes in vitro. Immunofluorescence screening with the antibody of greater than 250 isolates of the parasite finds the inhibitory epitope expressed by only 18% of strains. The glycoprotein is metabolically labelled with methionine, cysteine, histidine and glucosamine but incorporates little lysine or leucine. It is synthesized early in schizogony and remains, without any apparent processing, on the surface of released merozoites where it is demonstrated by immuno-electronmicroscopy and also by vectorial radio-iodination.
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