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  • Title: A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human).
    Author: Schwartz GP, Burke GT, Katsoyannis PG.
    Journal: Proc Natl Acad Sci U S A; 1989 Jan; 86(2):458-61. PubMed ID: 2643113.
    Abstract:
    An insulin analogue that embodies two distinct structural modifications, each of which independently increases insulin activity, has been synthesized and evaluated for biological activity. The analogue, des-(B26-B30)-[AspB10,TyrB25-NH2]insulin is the most potent insulin analogue yet described; it displays an 11- to 13-fold higher activity than natural insulin. The findings are discussed with regard to the receptor-binding domains of insulin.
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