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  • Title: Extracorporeal Photopheresis in the Treatment of Mycosis Fungoides and Sézary Syndrome.
    Author: Zic JA.
    Journal: Dermatol Clin; 2015 Oct; 33(4):765-76. PubMed ID: 26433848.
    Abstract:
    Extracorporeal photopheresis (ECP) is an immunomodulating procedure that leads to an expansion of peripheral blood dendritic cell populations and an enhanced TH1 immune response in cutaneous T-cell lymphoma (CTCL). Because of its excellent side effect profile and moderate efficacy, ECP is considered first-line therapy for erythrodermic mycosis fungoides (MF) and Sézary syndrome. Patients with a measurable but low blood tumor burden are most likely to respond to ECP, and the addition of adjunctive immunostimulatory agents may also increase response rates. There may be a role for ECP in the treatment of refractory early stage MF, but data are limited.
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