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  • Title: Thermodynamic Analysis of Allosteric and Chelate Cooperativity in Di- and Trivalent Ammonium/Crown-Ether Pseudorotaxanes.
    Author: Nowosinski K, von Krbek LK, Traulsen NL, Schalley CA.
    Journal: Org Lett; 2015 Oct 16; 17(20):5076-9. PubMed ID: 26440053.
    Abstract:
    A detailed thermodynamic analysis of the axle-wheel binding in di- and trivalent secondary ammonium/[24]crown-8 pseudorotaxanes is presented. Isothermal titration calorimetry (ITC) data and double mutant cycle analyses reveal an interesting interplay of positive as well as negative allosteric and positive chelate cooperativity thus providing profound insight into the effects governing multivalent binding in these pseudorotaxanes.
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