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  • Title: Constitutive mutants in the yeast pheromone response: ordered function of the gene products.
    Author: Blinder D, Bouvier S, Jenness DD.
    Journal: Cell; 1989 Feb 10; 56(3):479-86. PubMed ID: 2644047.
    Abstract:
    The alpha factor pheromone inhibits the division of yeast a cells. A general method was developed for isolating mutants that exhibit constitutive activation of the pheromone response pathway. A dominant allele of the STE4 locus was recovered in addition to recessive mutations in the SCG1 gene. SCG1 and STE4 are known to encode G alpha and G beta homologs, respectively. Analysis of double mutants suggests that the STE4 gene product functions after the SCG1 product but before the STE5 product.
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