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  • Title: Detection of a specific isoform of alpha-actinin with antisera directed against dystrophin.
    Author: Hoffman EP, Watkins SC, Slayter HS, Kunkel LM.
    Journal: J Cell Biol; 1989 Feb; 108(2):503-10. PubMed ID: 2645301.
    Abstract:
    We have characterized a protein immunologically related to dystrophin, the protein product of the Duchenne muscular dystrophy gene. We identify this related protein as a fast-twitch glycolytic isoform (mouse extensor digitorum longus-specific) of myofibrillar alpha-actinin. This specific isoform of alpha-actinin exhibits a more restricted pattern of expression in skeletal muscle than fast-twitch-specific isoforms of both myosin and Ca2+-ATPase. Our results provide evidence that dystrophin and myofibrillar alpha-actinin are related proteins, reinforcing the previous data concerning the sequence homologies noted between nonmuscle cytoskeletal alpha-actinin and dystrophin. In addition, we describe the first antisera directed against a specific myofibrillar skeletal muscle isoform of alpha-actinin.
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