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  • Title: Pulmonary Manifestations of Primary Immunodeficiency Disorders.
    Author: Nonas S.
    Journal: Immunol Allergy Clin North Am; 2015 Nov; 35(4):753-66. PubMed ID: 26454317.
    Abstract:
    Pulmonary disease, ranging from infectious pneumonia, lung abscess, and empyema to structural lung diseases to malignancy, significantly increase morbidity and mortality in primary immune deficiency. Treatment with supplemental immunoglobulin (intravenous or subcutaneous) and antimicrobials is beneficial in reducing infections but are largely ineffective in preventing noninfectious complications, including interstitial lung disease, malignancy, and autoimmune disease. A low threshold for suspecting pulmonary complications is necessary for the early diagnosis of pulmonary involvement in primary immunodeficiency disorders, before irreversible damage is done, to improve patient outcomes.
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