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  • Title: [Drug treatment of nausea and vomiting caused by cancer chemotherapy].
    Author: Havsteen H, Kjaer M.
    Journal: Ugeskr Laeger; 1989 Feb 13; 151(7):430-4. PubMed ID: 2645736.
    Abstract:
    Only two classes of antiemetics have documented effect and acceptable side effects on nausea and vomiting induced by cancer chemotherapy: Phenothiazines in non-cisplatinum containing chemotherapy and the dopamine antagonist metoclopramide in cisplatinum treatment. Steroids have no effect as single drugs with cisplatinum and their effect with other types of chemotherapy has not been clarified in detail. The combination of metoclopramide and steroids has documented superiority compared with single drug treatment in cisplatinum containing chemotherapy. The newly developed and still experimental serotonin antagonists have initially shown very promising results but further studies are required to define their role in the antiemetic treatment with cancer chemotherapy. Treatment of chemotherapy induced nausea and vomiting has improved considerably in the last few years but, generally, the results are still unsatisfactory. There is an urgent need for new drugs and combinations in the amelioration of these troublesome side effects of cancer chemotherapy.
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