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  • Title: Bioactivity of synthetic C-terminal fragment of rat pancreastatin on endocrine pancreas.
    Author: Funakoshi A, Miyasaka K, Kitani K, Tamamura H, Funakoshi S, Yajima H.
    Journal: Biochem Biophys Res Commun; 1989 Feb 15; 158(3):844-9. PubMed ID: 2645871.
    Abstract:
    A C-terminal fragment of rat pancreastatin, 26-residue peptide amide was synthesized by the Fmoc-based solid phase method and its biological activity was evaluated for the first time in the conscious rat. Rat pancreastatin inhibited glucose-stimulated insulin secretion and elevated blood glucose levels in a concentration of 10 nmol/kg/h. The relative molar potency of that of porcine is equivalent. This study suggests that the synthetic rat pancreastatin has a biological activity, and may play a physiological role in the endocrine pancreas.
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