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  • Title: Determination of MICs of levofloxacin for Mycobacterium tuberculosis with gyrA mutations.
    Author: Kambli P, Ajbani K, Nikam C, Khillari A, Shetty A, Udwadia Z, Georghiou SB, Rodwell TC, Catanzaro A, Rodrigues C.
    Journal: Int J Tuberc Lung Dis; 2015 Oct; 19(10):1227-9. PubMed ID: 26459538.
    Abstract:
    The purpose of the present study was to correlate gyrA mutations found in Mycobacterium tuberculosis isolates using the GenoType(®) MTBDRsl assay with minimum inhibitory concentrations of the fluoroquinolone levofloxacin (LVX). Of 123 archived clinical M. tuberculosis isolates evaluated, 93 isolates had an Ala90Val, Ser91Pro, Asp94Ala, Asn/Tyr, Gly or His mutation and 30 were wild-type. Phenotypically, gyrA mutations Ala90Val, Ser91Pro or Asp94Ala showed a low level of resistance to LVX, while Asp94Asn/Tyr, Asp94Gly or Asp94His mutations had high-level resistance.
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