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  • Title: Insulin binding to erythrocytes and fatty acid composition of erythrocyte membrane phospholipids in healthy men.
    Author: Pelikánová T, Kohout M, Hilgertová J, Rase J, Farská I, Válek J.
    Journal: Clin Chim Acta; 1989 Feb 15; 179(2):197-200. PubMed ID: 2646038.
    Abstract:
    The relationship between specific insulin binding to insulin receptors on erythrocytes and erythrocyte membrane phospholipid fatty acid pattern was evaluated in 11 healthy men. A significant negative correlation between insulin binding and the proportion of w-6 family essential fatty acids, especially linoleic acid (r = -0.82, p less than 0.01) and arachidonic acid (r = -0.73, p less than 0.05) in erythrocyte membrane was found. On the other hand significant positive correlation between insulin binding and the content of nonessential fatty acids (r = +0.65, p less than 0.05) was seen. Data presented support the hypothesis that the fatty acid composition of membrane phospholipids may modify properties of insulin receptors.
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