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  • Title: Sensitive discrimination of stable mismatched base pairs by an abasic site modified fluorescent probe and lambda exonuclease.
    Author: Wu T, Xiao X, Gu F, Zhao M.
    Journal: Chem Commun (Camb); 2015 Dec 21; 51(98):17402-5. PubMed ID: 26465212.
    Abstract:
    An abasic site modified fluorescent probe has been developed which enabled the rapid discrimination of stable single mismatched base pairs by lambda exonuclease with remarkably high discrimination factors (447 for T:G and 238 for A:G). This method allowed sensitive detection of single nucleotide variation at very low abundances (0.02-0.05% mutant-to-wild type).
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