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  • Title: A bio-engineered rubella E1 antigen.
    Author: Terry GM, Ho-Terry L, Londesborough P, Rees KR.
    Journal: Arch Virol; 1989; 104(1-2):63-75. PubMed ID: 2647062.
    Abstract:
    The major rubella envelope protein, E1, and a segment of it, comprising amino acids 207-353, have been separately expressed as fusion proteins with the IgG binding region of Staphylococcus aureus protein A in Escherichia coli. The proteins carry E1-specific antigenicity recognized by monoclonal antibodies raised against whole virus confirming that correct glycosylation is not required for antigenicity. The use of these bioengineered antigens in immunoassays for diagnosis of rubella infection and for immunization in experimental animals is described.
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