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  • Title: Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells.
    Author: Jang H, Lee JW, Lee C, Jin Q, Choi JY, Lee D, Han SB, Kim Y, Hong JT, Lee MK, Hwang BY.
    Journal: Arch Pharm Res; 2016 Jan; 39(1):127-32. PubMed ID: 26474586.
    Abstract:
    A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3-20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8-12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5-28.5 μM.
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