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  • Title: Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata.
    Author: Gao Y, Yu AL, Li GT, Hai P, Li Y, Liu JK, Wang F.
    Journal: Fitoterapia; 2015 Dec; 107():44-48. PubMed ID: 26474672.
    Abstract:
    Five new hexacyclic monoterpenoid indole alkaloids, rauvovertine A (1), 17-epi-rauvovertine A (2), rauvovertine B (3), 17-epi-rauvovertine B (4), and rauvovertine C (5) together with 17 known analogues were isolated from the stems of Rauvolfia verticillata. Compounds 1/2 and 3/4 were obtained as C-17 epimeric mixtures due to rapid hemiacetal tautomerism in solution. The structures of 1-5 were established by spectroscopic analysis and with the aid of molecular modeling. The new alkaloids were evaluated for their cytotoxicity in vitro against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.
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