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  • Title: GTP-dependent Ca2+ release from rat liver microsomes. Vesicle fusion is not required.
    Author: Kleineke J, Schröder A, Söling HD.
    Journal: FEBS Lett; 1989 Mar 13; 245(1-2):274-8. PubMed ID: 2647523.
    Abstract:
    The GTP-dependent calcium release from rat liver microsomes is known to be promoted in the presence of colloids like polyethyleneglycol (PEG), polyvinylpyrrolidine, or albumin. Dawson et al. [(1987) Biochem. J. 244, 87-92] using the 'fusogen' PEG have concluded that both GTP-induced calcium efflux and the enhancement of InsP3-promoted calcium release in the presence of GTP could be attributed to a GTP-dependent vesicle fusion. Here, using the more physiological colloid albumin we report that GTP-induced calcium release from rat liver microsomes may not be linked to vesicle fusion.
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