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  • Title: Treatment of premenstrual depression with nortriptyline: a pilot study.
    Author: Harrison WM, Endicott J, Nee J.
    Journal: J Clin Psychiatry; 1989 Apr; 50(4):136-9. PubMed ID: 2647713.
    Abstract:
    There are no reports on treatment of premenstrual syndrome with antidepressants, although depression is a common symptom of the syndrome. Eleven women who met DSM-III-R criteria for late luteal phase dysphoric disorder were treated with nortriptyline in an open pilot study after they failed to respond to placebo or another medication. Eight of 11 patients had a good therapeutic response. The efficacy of antidepressants in the treatment of premenstrual depression needs confirmation with double-blind studies.
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