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  • Title: Rhodium(III)-Catalyzed Amidation of Unactivated C(sp(3) )-H Bonds.
    Author: Wang H, Tang G, Li X.
    Journal: Angew Chem Int Ed Engl; 2015 Oct 26; 54(44):13049-52. PubMed ID: 26480337.
    Abstract:
    Nitrogenation by direct functionalization of C-H bonds represents an important strategy for constructing C-N bonds. Rhodium(III)-catalyzed direct amidation of unactivated C(sp(3) )-H bonds is rare, especially under mild reaction conditions. Herein, a broad scope of C(sp(3) )-H bonds are amidated under rhodium catalysis in high efficiency using 3-substituted 1,4,2-dioxazol-5-ones as the amide source. The protocol broadens the scope of rhodium(III)-catalyzed C(sp(3) )-H activation chemistry, and is applicable to the late-stage functionalization of natural products.
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