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  • Title: Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with group A streptococci.
    Author: Good MF, Pandey M, Batzloff MR, Tyrrell GJ.
    Journal: Expert Rev Vaccines; 2015; 14(11):1459-70. PubMed ID: 26485214.
    Abstract:
    Group A streptococcal (Streptococcus pyogenes) diseases remain a major public health problem in developing countries as well as in the indigenous populations of developed countries. In view of the large number of Group A streptococcal infections and the potential for sequelae such as rheumatic heart disease, control strategies including the development of an anti-streptococcal vaccine that is able to prevent infection and colonization is important. In this article, we discuss the epidemiology and strain variability of Group A streptococcus and how this is rendering vaccine development more challenging. We discuss vaccine strategies with a focus on the conserved region of the M protein and present a viewpoint for the impediments and the way forward.
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