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  • Title: Label-Free and Real-Time Detection of Avian Influenza Using Nanowire Field Effect Transistors.
    Author: Ahn JH, Im M, Park TJ, Lee SY, Choi YK.
    Journal: J Biomed Nanotechnol; 2015 Sep; 11(9):1640-3. PubMed ID: 26485932.
    Abstract:
    Real-time and label-free detection of antibodies from avian influenza (anti-AI) in an aqueous solution is demonstrated with the use of a nanowire field effect transistor. A real-time measurement system is constructed without leakage paths through the solution medium. The current through the nanowire changes significantly after an injection of an anti-AI solution onto the device, which was previously functionalized by the antigen of AI as a probe of anti-AI. In contrast, no significant response arises when an anti-AI solution is injected onto a non-functionalized device. Therefore, the real-time detection of specific antibody-antigen interaction of the AI is successfully implemented for a chip-based biosensor.
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