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  • Title: Antibiotic prophylaxis for shunt surgery of children: a systematic review.
    Author: Xu H, Hu F, Hu H, Sun W, Jiao W, Li R, Lei T.
    Journal: Childs Nerv Syst; 2016 Feb; 32(2):253-8. PubMed ID: 26499129.
    Abstract:
    OBJECTIVE: The object of this study was to evaluate the clinical effectiveness of antibiotic prophylaxis in children who underwent placement of intracranial ventricular shunts. METHODS: In this paper, the authors report a systematic review and meta-analysis of infection rate for pediatric shunt implantation surgery. Randomized or non-randomized controlled trials for comparing the use of prophylactic antibiotics in intracranial ventricular shunt procedures with placebo or no antibiotics were included in the review. RESULTS: Seven published reports of eligible studies involving 694 participants meet the inclusion criteria. Compared with the control group, antibiotic prophylaxis had made a significant difference in infection rate (RR = 0.59, 95% CI = 0.38, 0.90, P < 0.05). CONCLUSION: Although current evidence demonstrates that antibiotic prophylaxis can lead to a significant reduction of the infection rate of shunt surgery, more evidence from advanced multi-center studies is needed to provide instruction for the use of prophylactic antibiotics.
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