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  • Title: [Successful treatment with fondaparinux in heparin-induced thrombocytopenia and thrombosis].
    Author: Seculini Patiño CE, Pascualini MF, Tabares AH.
    Journal: Medicina (B Aires); 2015; 75(5):307-10. PubMed ID: 26502466.
    Abstract:
    Heparin induced thrombocytopenia (HIT) is an immune-mediated adverse reaction characterized by thrombocytopenia and paradoxical arterial or venous thrombosis, due to the formation IgG antibodies directed to a multimolecular complex of heparin-platelet factor 4 (PF4). Fondaparinux is a selective factor Xa inhibitor with little affinity for PF4 and thus less likely to induce an immune response, making fondaparinux a potentially useful drug for the treatment of HIT. Herein we report the case of a 73 years old woman with HIT associated with arterial and venous thrombosis that was successfully treated with fondaparinux, with normalization of the platelet countand without progression of thrombosis.
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