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  • Title: Novobiocin Inhibits the Antimicrobial Resistance Acquired through DNA Damage-Induced Mutagenesis in Acinetobacter baumannii.
    Author: Jara LM, Pérez-Varela M, Corral J, Arch M, Cortés P, Bou G, Aranda J, Barbé J.
    Journal: Antimicrob Agents Chemother; 2016 Jan; 60(1):637-9. PubMed ID: 26503651.
    Abstract:
    Acinetobacter baumannii, a worldwide emerging nosocomial pathogen, acquires antimicrobial resistances in response to DNA-damaging agents, which increase the expression of multiple error-prone DNA polymerase components. Here we show that the aminocoumarin novobiocin, which inhibits the DNA damage response in Gram-positive bacteria, also inhibits the expression of error-prone DNA polymerases in this Gram-negative multidrug-resistant pathogen and, consequently, its potential acquisition of antimicrobial resistance through DNA damage-induced mutagenesis.
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