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  • Title: Extraskeletal Myxoid Chondrosarcoma Presenting as a Plantar Fibroma: Case Report and Review of the Literature.
    Author: Lockyer MG, Rosen DG.
    Journal: Anticancer Res; 2015 Nov; 35(11):6171-4. PubMed ID: 26504046.
    Abstract:
    BACKGROUND: Extraskeletal myxoid chondrosarcoma is a rare tumor with an indolent course, high propensity for local recurrence, metastases, and propensity for the proximal extremities of middle-aged males. CASE REPORT: We present the case of a 44-year-old man with an extraskeletal myxoid chondrosarcoma in the plantar fascia of the medial arch initially thought to be a plantar fibroma. Magnetic resonance imaging of the lesion demonstrated a lobulated subcutaneous mass plantar to the tarsal bones and inseparable from the fascia. Microscopic examination revealed a lobulated lesion composed of cords and nests of round to spindled malignant cells in a blue-gray myxoid matrix surrounded by fibrous septae. The malignant cells displayed variable positivity for S-100. CONCLUSION: Plantar extraskeletal myxoid chondrosarcoma is a rare occurrence. It should always be considered in the differential diagnosis of masses arising in the plantar fascia of the foot.
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