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  • Title: [Regulation of HTLV-1 gene expression and its relevance to proliferation of the infected cells].
    Author: Seiki M.
    Journal: Gan To Kagaku Ryoho; 1989 Mar; 16(3 Pt 2):516-21. PubMed ID: 2650630.
    Abstract:
    Proliferation of HTLV-1 after infection is one of the crucial steps that affects development of adult T cell leukemia. In addition, one of the regulatory factors, tax protein, activates not only viral transcription from the LTR but also transcription of genes coding IL-2 and IL-2 receptor and eventually supposed to induce proliferation of infected T cells. However, expression of tax protein is regulated negatively by another viral regulatory factor, rex protein, in a novel fashion. The process of ATL development is discussed in relation to the regulation of viral gene expression.
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