These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction.
    Author: Diagne AB, Li S, Perkowski GA, Mrksich M, Thomson RJ.
    Journal: ACS Comb Sci; 2015 Nov 09; 17(11):658-62. PubMed ID: 26521847.
    Abstract:
    Development of the self-assembled monolayer/MALDI mass spectrometry (SAMDI) platform to enable a high-throughput optimization of a traceless Petasis reaction is described. More than 1800 unique reactions were conducted simultaneously on an array of self-assembled monolayers of alkanethiolates on gold to arrive at optimized conditions, which were then successfully transferred to the solution phase. The utility of this reaction was validated by the efficient synthesis of a variety of di- and trisubstituted allenes.
    [Abstract] [Full Text] [Related] [New Search]