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  • Title: Sunitinib loaded chitosan nanoparticles formulation and its evaluation.
    Author: Joseph JJ, Sangeetha D, Gomathi T.
    Journal: Int J Biol Macromol; 2016 Jan; 82():952-8. PubMed ID: 26522243.
    Abstract:
    The nano-polymeric pharmaceutical excipient such as chitosan nanoparticles (CS-NPs) were synthesized for formulating the anticancer drug Sunitinib (STB). The formulation was done through the simple ionic cross linking method. The prepared formulation was characterized by DLS, SEM, FT-IR and XRD. The DLS study reveals that the Sunitinib loaded chitosan nanoparticles (SNB-CS-NPs) were in the size range of < 200 nm. Encapsulation of Sunitinib and validation for the formulation was done using UV spectrophotometry. In vitro drug release and its cytotoxic studies were performed for STB-CS-NPs. This study implies the novel drug delivery system for Sunitinib for the effective sustained delivery.
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