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  • Title: Optimised extraction of Erythronium sibiricum bulb polysaccharides and evaluation of their bioactivities.
    Author: Chen C, Kasimu R, Xie X, Zheng Y, Ding W.
    Journal: Int J Biol Macromol; 2016 Jan; 82():898-904. PubMed ID: 26526177.
    Abstract:
    In this study, the extraction of Erythronium sibiricum bulb polysaccharides (ESBP) through hot water decoction was optimised using response surface methodology (RSM) and a three-level, four-factor Box-Behnken design. The optimum extraction conditions were as follows: extraction time of 4.28h, extraction temperature of 90°C, ratio of liquid to raw material of 37 mL/g and extraction cycle number of three. The experimental yield (37.25%±0.17%) agreed with the predicted value of the RSM model (37.465%). Preliminary ESBP characterisation was conducted through physicochemical analysis. Biological activity test results showed that ESBP exhibited antioxidant activities and excellent anti-inflammatory and analgesic activities, indicating its potential as an anti-inflammatory and analgesic agent.
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