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  • Title: Timolol-pilocarpine combined vs timolol and pilocarpine given separately.
    Author: Söderström MB, Wallin O, Granström PA, Thorburn W.
    Journal: Am J Ophthalmol; 1989 May 15; 107(5):465-70. PubMed ID: 2653044.
    Abstract:
    In a controlled, double-observer, multicenter study, we compared the effect of a fixed combination of timolol 0.5%-pilocarpine 4% twice a day with that of timolol 0.5% twice a day plus pilocarpine 4% three times a day in 80 patients with open-angle glaucoma whose intraocular pressure was greater than 21 mm Hg on timolol 0.5% twice a day alone. Administered twice daily, the combination drug lowered intraocular pressure as effectively as concomitant treatment with timolol twice a day and pilocarpine three times a day. No statistically significant differences in reduction of intraocular pressure were found between the two groups nor were any unexpected side effects observed.
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