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  • Title: [Effect of prodigiozan on the glucocorticoid and insulin ratio in the blood serum of white rats].
    Author: Panin LE, Smolentseva II, Atuchina NV, Tret'iakova T.
    Journal: Biull Eksp Biol Med; 1989 Mar; 107(3):259-60. PubMed ID: 2653449.
    Abstract:
    Significant hypertrophy of the adrenal glands was observed in Wistar rats the day after a single prodigiozan administration. This did not change the level of glucocorticoids in blood serum, but increased the concentration in insulin. Analysis of steroidogenesis in the adrenal glands indicated significant increase in steroid's production in the experimental group of rats as compared to the control. An increase of glucoso-6-phosphate dehydrogenase and hexokinase activity in adrenal tissue was also observed. The results suggest that stimulation of corticosteroid's secretion was accompanied by an increase in their reception to tissues which caused an increase of nonspecific resistance of the organism.
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