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  • Title: Pharmacokinetics of cefotaxime and desacetylcefotaxime in the newborn.
    Author: Aujard Y, Brion F, Jacqz-Aigrain E, Kasse MC, Chretien P, Criqui C, Mathieu H.
    Journal: Diagn Microbiol Infect Dis; 1989; 12(1):87-91. PubMed ID: 2653716.
    Abstract:
    A study of the pharmacokinetic parameters of cefotaxime (CTX) and desacetylcefotaxime (dCTX) in newborns was conducted; the former is commonly used for neonatal infections. The elimination half life of CTX correlated with gestational age (GA) and postnatal age (PNA). Elimination of dCTX was longer permitting a synergistic or additive effect with CTX against Gram-negative bacteria. CTX is indicated in the treatment of neonatal sepsis because of the increasing resistance of Escherichia coli to ampicillin and its good efficacy against group B streptococcus.
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