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  • Title: Evaluation of selected indicators of antioxidant status in patients with head and neck cancer.
    Author: Mrowicka M, Zielińska-Bliźniewska H, Pietkiewicz P, Olszewski J, Majsterek I.
    Journal: Otolaryngol Pol; 2015; 69(5):44-50. PubMed ID: 26537644.
    Abstract:
    INTRODUCTION: The aim of the study was to evaluate lipid peroxidation (TBARS) and the antioxidant enzymatic barrier in patients with head and neck cancer and in healthy controls. MATERIAL AND METHODS: Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA) were measured by spectrometry in red blood cells of 22 patients and healthy controls. RESULTS: Decreased activity of SOD, CAT, and GPx as well as an increased concentration of MDA was found in cancer patients in comparison to healthy controls. DISCUSSION: Increased lipid peroxidation in red blood cells of cancer patients indicates an intensification of oxidative stress reactions. Measurements of the activity of the antioxidant enzymes point unambiguously to a reduced antioxidant capacity in head and neck cancer patients. However, this was a pilot study with a low number of participants. Moreover, future research should take into account genetic and extragenetic factors.
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