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  • Title: Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.
    Author: Yesilyurt V, Webber MJ, Appel EA, Godwin C, Langer R, Anderson DG.
    Journal: Adv Mater; 2016 Jan 06; 28(1):86-91. PubMed ID: 26540021.
    Abstract:
    Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.
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