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  • Title: High Prevalence of Biocide Resistance Determinants in Staphylococcus aureus Isolates from Three African Countries.
    Author: Conceição T, Coelho C, de Lencastre H, Aires-de-Sousa M.
    Journal: Antimicrob Agents Chemother; 2016 Jan; 60(1):678-81. PubMed ID: 26552979.
    Abstract:
    We assessed the prevalence of six biocide resistance genes among 82 methicillin-resistant Staphylococcus aureus (MRSA) and 219 methicillin-susceptible S. aureus (MSSA) isolates from three African countries; the prevalence was very high for sepA (95.3%), mepA (89.4%), and norA (86.4%), intermediate for lmrS (60.8%) and qacAB (40.5%), and low for smr (3.7%). A significant association between biocide resistance genes and antibiotic resistance was observed, and a new cutoff MIC of ≥1 mg/liter for chlorhexidine nonsusceptibility was defined.
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