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  • Title: Relief of epigastric pain in nonulcer dyspepsia: controlled trial of the promotility drug cisapride.
    Author: De Nutte N, Van Ganse W, Witterhulghe M, Defrance P.
    Journal: Clin Ther; 1989; 11(1):62-8. PubMed ID: 2655906.
    Abstract:
    In a randomized, double-blind, placebo-controlled study, 32 patients with nonulcer dyspepsia received 5 mg of cisapride or placebo three times daily for four weeks after a two-week run-in phase on placebo. Limited antacid use was allowed. Cisapride was superior to placebo in reducing the intensity of epigastric pain at two weeks (P = 0.03) and four weeks (P = 0.01). At the end of treatment, 82% of the cisapride-treated patients and 43% of the controls had no or only mild pain. Minor, gastrointestinal side effects were observed in two cisapride-treated patients and in one control.
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