These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Recurrent Respiratory Infections Revealing CD8α Deficiency.
    Author: Dumontet E, Osman J, Guillemont-Lambert N, Cros G, Moshous D, Picard C.
    Journal: J Clin Immunol; 2015 Nov; 35(8):692-5. PubMed ID: 26563160.
    Abstract:
    CD8A encodes the CD8α chain of the dimeric CD8 protein, a critical coreceptor of cytotoxic T cells. We report here the comprehensive immunological evaluation of a child with a CD8A missense mutation, providing evidence that CD8 deficiency increases susceptibility to recurrent respiratory infections without interfering with the TCR-mediated proliferation of T cells. These observations expand the known phenotypes associated with CD8 deficiency.
    [Abstract] [Full Text] [Related] [New Search]