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  • Title: Characterization of the novel T4-like Salmonella enterica bacteriophage STP4-a and its endolysin.
    Author: Li M, Li M, Lin H, Wang J, Jin Y, Han F.
    Journal: Arch Virol; 2016 Feb; 161(2):377-84. PubMed ID: 26563319.
    Abstract:
    While screening for new antimicrobial agents for multidrug-resistant Salmonella enterica, the novel lytic bacteriophage STP4-a was isolated and characterized. Phage morphology revealed that STP4-a belongs to the family Myoviridae. Bacterial challenge assays showed that different serovars of Salmonella enterica were susceptible to STP4-a infection. The genomic characteristics of STP4-a, containing 159,914 bp of dsDNA with an average GC content of 36.86 %, were determined. Furthermore, the endolysin of STP4-a was expressed and characterized. The novel endolysin, LysSTP4, has hydrolytic activity towards outer-membrane-permeabilized S. enterica and Escherichia coli. These results provide essential information for the development of novel phage-based biocontrol agents against S. enterica.
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