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Title: Four New Flavonoids with α-Glucosidase Inhibitory Activities from Morus alba var. tatarica. Author: Zhang YL, Luo JG, Wan CX, Zhou ZB, Kong LY. Journal: Chem Biodivers; 2015 Nov; 12(11):1768-76. PubMed ID: 26567954. Abstract: Four new flavonoids, mortatarins A-D (1-4, resp.), along with eight known flavonoids (5-12) were isolated from the root bark of Morus alba var. tatarica. Their structures were established on the basis of spectroscopic data analysis, and the absolute configuration of 4 was determined by analysis of its CD spectrum. All isolates were tested for inhibitory activities against α-glucosidase. Compounds 4, 7, and 8 exhibited a significant degree of inhibition with IC50 values of 5.0 ± 0.3, 7.5 ± 0.5, and 5.9 ± 0.2 μM, respectively.[Abstract] [Full Text] [Related] [New Search]