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  • Title: Visible-Light/Photoredox-Mediated sp(3) C-H Functionalization and Coupling of Secondary Amines with Vinyl Azides in Flow Microreactors.
    Author: Tiwari DK, Maurya RA, Nanubolu JB.
    Journal: Chemistry; 2016 Jan 11; 22(2):526-30. PubMed ID: 26573105.
    Abstract:
    Structurally diverse imidazole derivatives were synthesized by a visible-light/[Ru(bpy)3 ][(PF6 )2 ]-mediated coupling of vinyl azides and secondary amines in flow microreactors. This operationally simple and atom-economical protocol allows the formation of three new C-N bonds through the functionalization of sp(3)  C-H bonds adjacent to the secondary nitrogen atom. In order to get mechanistic insight of the coupling reaction, several control experiments were carried out and discussed.
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