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  • Title: Positive chronotropic and inotropic responses to guanosine in the isolated dog atrium.
    Author: Chiba S, Kobayashi M, Furukawa Y.
    Journal: Eur J Pharmacol; 1978 Jun 01; 49(3):319-21. PubMed ID: 26581.
    Abstract:
    The effects of guanosine on chronotropism and inotropism in isolated dog atria were studied in spontaneously beating preparations which were suspended in a bath perfused with arterial blood from a carotid artery of a heparinized support dog. Guanosine administered into the cannulated sinus node artery in a dose range of 30 microgram to 3 mg produced a dose-related positive inotropic and chronotropic effect. The positive responses to guanosine were not inhibited by treatment with propranolol or a non-depressant beta-blocker, carteolol, in doses which blocked responses to norepinephrine. From these results, it is concluded that guanosine has a direct effect on atrial rate and contractility.
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