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  • Title: [Drug intolerance caused by pseudo-allergic reactions].
    Author: Ring J.
    Journal: Wien Med Wochenschr; 1989 Apr 15; 139(6-7):130-4. PubMed ID: 2658340.
    Abstract:
    The symptomatology of allergic diseases may be imitated by non-immunological, so-called "pseudo-allergic" reactions. Phenocopies of any type of allergic reaction may occur. Pseudo-allergic drug reactions may be caused by the active components as well as by additives. Anaphylactoid pseudo-allergic reactions are of special clinical interest. Their pathomechanism has not been conclusively elucidated yet. Based on clinical and experimental data, we discuss some hypothetical mechanisms of a few compounds, always keeping in mind the possibility of allergic mechanisms not yet identified. For the diagnosis of pseudo-allergic drug reactions we need provocation tests, as skin tests are not possible, and routine in-vitro assays are not available.
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